Cancer is one of the leading causes of death worldwide, and finding effective treatments for this disease is a major challenge for medical research. However, a recent breakthrough by a research team from a pharmaceutical company has shown promising results in developing a novel drug for cancer treatment, thanks to the use of MBraun Glove Box Workstations.
MBraun Glove Box Workstations are state-of-the-art systems that provide a controlled and inert environment for various applications and experiments. They are widely used in research and development of emerging technologies, such as lithium batteries, chemical, OLED, and welding. They can also be customized with a range of features and equipment to meet specific research needs and expectations.
The research team used MBraun Glove Box Workstations to synthesize and test a new drug candidate that targets a specific protein involved in cancer cell growth and survival. The drug candidate belongs to a class of compounds called disulfiram derivatives, which are derived from an anti-alcoholism drug that has been repurposed for cancer therapy.
The team faced several challenges in developing the drug candidate, such as ensuring its purity, stability, and bioavailability. They also had to protect the drug candidate from moisture, oxygen, and other contaminants that could affect its activity and efficacy. To overcome these challenges, the team relied on the advantages and features of MBraun Glove Box Workstations, such as:
- The powerful gas purifier unit that removes oxygen and water from the working gas, creating a dry and oxygen-free atmosphere inside the glove box chamber. This prevents oxidation and degradation of the drug candidate and ensures its quality and potency.
- The integrated high vacuum feedthroughs that allow the transfer of materials and equipment in and out of the glove box chamber without compromising the integrity of the system. This facilitates the synthesis and testing of the drug candidate and reduces the risk of contamination.
- The stainless-steel encapsulated blower that circulates the working gas in a closed loop, maintaining a constant pressure and temperature inside the glove box chamber. This creates a stable and uniform environment for the drug candidate and enhances its performance.
The team also used MBraun’s accessories and spare parts, such as the antechamber, the freezer, the oven, and the analytical balance, to further optimize their workflow and efficiency. They also benefited from MBraun’s technical service, calibration certificates, maintenance contracts, and technical support, which ensured the reliability and functionality of the glove box systems.
The team reported that the drug candidate showed remarkable anti-cancer activity in preclinical studies, both in vitro and in vivo. The drug candidate was able to inhibit the growth and survival of various cancer cell lines, including lung, breast, prostate, and colon cancers. It also induced apoptosis, or programmed cell death, in cancer cells, while sparing normal cells. Moreover, the drug candidate exhibited a favorable pharmacokinetic profile, with good absorption, distribution, metabolism, and excretion.
The team attributed their success to the use of MBraun Glove Box Workstations, which enabled them to develop a novel drug for cancer treatment with high quality and efficiency. They also expressed their gratitude to MBraun for providing them with a superior glove box system and a comprehensive service and support. They are now planning to conduct further studies and clinical trials to validate the safety and efficacy of the drug candidate in humans.
The team’s discovery is a significant contribution to the field of cancer research and drug development, and a testament to the potential and value of MBraun Glove Box Workstations. MBraun Glove Box Workstations are not only the preferred choice of many researchers and industries, but also a key to unlocking new solutions and innovations for various challenges and opportunities.
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